@khill-fbmc I checked with a couple engineers internally who focus on performance optimization and their sense is that it shouldn't matter which way you configure the query in terms of performance overhead. Hope this helps - I know this isn't a super ground-breaking answer 
If when monitoring app performance with the Debug console (great post on the feature if folks haven't checked it out) you do see differences, that could guide your decision making around how to set things up.
One thing to note - those event handlers run concurrently, so if a specific order of operations is necessary for actions that run on the same event, coordinating that timing in a script or via chained event handlers is the way to go. It's a common thing we see where folks building in Retool might put 2 -3 event handlers on a component for the same event and expect they'd run in the order that they are listed in the UI, but not necessarily!